Classically, which of the following clinical features represents a "red flag" for aggressive bone disease?

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Cachexia, or unintended weight loss and muscle wasting, is a red flag for aggressive bone disease as it suggests advanced and rapidly progressing disease. More dramatic pain in the morning and increased pain with physical activity are common in many musculoskeletal conditions and do not necessarily indicate aggressive bone disease. Increased mobility may actually be a positive sign in some cases.

Classically, Which of the Following Clinical Features Represents a "Red