The production of red blood cells is regulated by a feedback loop involving erythropoietin. In non-disease states, the production of red blood cells is equal to the destruction of red blood cells, thus maintaining sufficient red blood cells to deliver adequate oxygen to the body's tissues. However, when the number of red blood cells decrease and oxygen levels are low, erythropoietin is produced by the liver and kidneys to increase the production of red blood cells. Is this a positive or negative feedback loop? Explain your answer.
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