A cross between a male horse and a female donkey produces a mule. Mules are an example of

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Mules are an example of hybrid infertility because they are sterile and cannot reproduce. This is due to the difference in chromosome numbers between horses and donkeys, which makes it difficult for the mule's gametes to form properly. Temporal isolation refers to the fact that species mate at different times, gametic isolation refers to the inability of gametes to fuse due to biochemical differences, and zygote mortality refers to the death of a fertilized egg.

A Cross Between a Male Horse and a Female Donkey