Which Statement Is NOT True About How Various Conditions Will

Which statement is NOT true about how various conditions will effect the activity of an enzyme?

A) Higher temperatures generally increase the activity of an enzyme up to a point.
B) Above a certain range of temperatures, the protein of an enzyme is denatured.
C) A change in pH can cause an enzyme to be inactivated.
D) An enzyme's activity is generally reduced by an increase in substrate concentration.
E) When sufficient substrate is available, the active site will nearly always be occupied.