If a change in pH alters an allosteric site where an inhibitor binds, but doesn't change the active site for the intended substrate, it would be possible for an enzymatically controlled reaction to occur as normal.

Question

Quizplus · Accepted Answer

Allosteric inhibition occurs when a molecule binds to an allosteric site on an enzyme, causing a change in the enzyme's shape that inhibits its activity. If the pH changes the shape of the allosteric site for the inhibitor, but not the active site for the intended substrate, the enzyme can still bind and catalyze the substrate's reaction as normal. Therefore, a change in the pH may not affect the enzymatically controlled reaction if it only alters the allosteric site for the inhibitor.

If a Change in PH Alters an Allosteric Site Where