What event is usually responsible for terminating signal transduction by RTKs?
A)dephosphorylation of the receptor
B)degradation of the ligand
C)receptor internalization
D)phosphorylation of the receptor
E)acetylation of the receptor

Question

Quizplus · Accepted Answer

Receptor internalization is usually responsible for terminating signal transduction by RTKs. When the ligand binds to the receptor, it triggers the internalization of the complex, leading to the receptor being pulled away from the cell surface and eventually degraded. This process effectively shuts down the signaling cascade initiated by the binding of the ligand to the receptor. Dephosphorylation of the receptor and degradation of the ligand may play a role in terminating the signal, but they are not the primary mechanisms. Phosphorylation and acetylation of the receptor are not known to terminate signal transduction by RTKs.

What Event Is Usually Responsible for Terminating Signal Transduction by RTKs