What enzyme is responsible for recognizing a chemical alteration in the DNA and removing the base by cleavage of the bond holding the base to the deoxyribose sugar moiety?
A)an AP endonuclease
B)phosphodiesterase activity of polymerase $\beta$
C)5'-3' exonuclease
D)3'-5' exonuclease
E)DNA glycosylase

Question

What enzyme is responsible for recognizing a chemical alteration in the DNA and removing the base by cleavage of the bond holding the base to the deoxyribose sugar moiety?
A)an AP endonuclease
B)phosphodiesterase activity of polymerase $\beta$
C)5'->3' exonuclease
D)3'->5' exonuclease
E)DNA glycosylase

Quizplus · Accepted Answer

DNA glycosylase is the enzyme responsible for recognizing a chemical alteration in the DNA, such as damaged or incorrect bases, and removes the base by cleaving the bond holding the base to the deoxyribose sugar moiety. This process is known as base excision repair.

What Enzyme Is Responsible for Recognizing a Chemical Alteration in the DNA