Why does the isoleucyl-tRNA synthetase use two types of proofreading mechanisms to ensure its accurate aminoacylation?
A)It is not a very precise enzyme.
B)It is a very big enzyme.
C)Isoleucine is very hard to distinguish from valine,since they differ only by a single methylene group.
D)Isoleucine is very difficult to distinguish from glycine.
E)Isoleucine can spontaneously turn into phenylalanine.

Question

Quizplus · Accepted Answer

Isoleucine and valine have very similar chemical structures, differing only by a single methylene group. This makes it challenging for the isoleucyl-tRNA synthetase enzyme to distinguish between the two amino acids accurately. The enzyme uses two proofreading mechanisms to overcome this challenge and ensure accurate aminoacylation.

Why Does the Isoleucyl-TRNA Synthetase Use Two Types of Proofreading