What do studies suggest governs the "decision" to destroy a defective protein that has been unable to fold correctly and has been in the ER for an extended period of time?
A)a fast-acting ER enzyme that trims a mannose residue from an exposed end of the oligosaccharide of a protein
B)a slow-acting ER enzyme that trims a mannose residue from an exposed end of the oligosaccharide of a protein
C)a fast-acting cytoplasmic enzyme that trims a mannose residue from an exposed end of the oligosaccharide of a protein
D)a slow-acting nuclear enzyme that trims a mannose residue from an exposed end of the oligosaccharide of a protein
E)a slow-acting cytoplasmic enzyme that trims a mannose residue from an exposed end of the oligosaccharide of a protein

Question

Quizplus · Accepted Answer

Studies suggest that a slow-acting ER enzyme trims a mannose residue from an exposed end of the oligosaccharide of a protein, which is a signal for the recognition and degradation of the protein by the ER-associated degradation (ERAD) pathway. This is part of the quality control system in the ER, which helps to ensure that only properly folded proteins are transported to their final destination.

What Do Studies Suggest Governs the "Decision" to Destroy a Defective