What happened to COPI-coated vesicles within the cell when the cell was treated with GTP analogues that could not be hydrolyzed?
A)They accumulated in the nucleus.
B)They accumulated in the cytoplasm.
C)They fused into one giant vesicle that was seen in the cytoplasm.
D)They decreased substantially in number in the nucleus.
E)They decreased substantially in number in the cytoplasm.

Question

Quizplus · Accepted Answer

COPI-coated vesicles are involved in retrograde transport from the Golgi complex to the endoplasmic reticulum. GTP hydrolysis is important for the disassembly of COPI-coated vesicles. If the cell is treated with GTP analogues that cannot be hydrolyzed, the COPI-coated vesicles would not be able to disassemble and would accumulate in the cytoplasm. Therefore, the best choice is B, which states that they accumulated in the cytoplasm.

What Happened to COPI-Coated Vesicles Within the Cell When the Cell