What are the recognition signals for lysosomal enzymes that allow them to be localized correctly in lysosomes?
A)Lysosomal enzymes possess sulfated mannose residues on N-linked carbohydrate chains.
B)Lysosomal enzymes possess phosphorylated mannose residues on N-linked carbohydrate chains.
C)Lysosomal enzymes possess phosphorylated mannose residues on O-linked carbohydrate chains.
D)Lysosomal enzymes possess sulfated mannose residues on O-linked carbohydrate chains.
E)Lysosomal enzymes possess phosphorylated glucose residues on N-linked carbohydrate chains.

Question

Quizplus · Accepted Answer

Lysosomal enzymes are tagged for localization to lysosomes by the addition of phosphate groups to mannose residues on their N-linked oligosaccharides. This modification serves as a signal for mannose-6-phosphate receptors in the Golgi apparatus, which then direct the enzymes to lysosomes.

What Are the Recognition Signals for Lysosomal Enzymes That Allow