What would happen if the enzyme that adds phosphate groups to the appropriate mannose residues on the carbohydrate chains of lysosomal enzymes were defective?
A)Lysosomal enzymes would be localized to lysosomes.
B)Lysosomal enzymes would be localized to peroxisomes.
C)Lysosomal enzymes would continue through the Golgi complex to secretory vesicles and would eventually be secreted.
D)Lysosomal enzymes would be degraded.

Question

Quizplus · Accepted Answer

The appropriate addition of phosphate groups to mannose residues on lysosomal enzymes is necessary for their proper targeting to lysosomes. Without this modification, lysosomal enzymes would continue through the secretory pathway, ultimately being secreted outside of the cell instead of being sorted to lysosomes.

What Would Happen If the Enzyme That Adds Phosphate Groups