What kind of interaction is not involved in the binding of a substrate to a normally functioning enzyme?

Question

Quizplus · Accepted Answer

A permanent covalent bond is not involved in the binding of a substrate to a normally functioning enzyme. Enzymatic reactions involve temporary or transient covalent bonds such as covalent catalysis, where a covalent bond forms between the enzyme and substrate during the reaction but is later broken. The other interactions listed (H bonds, ionic bonds, hydrophobic interactions) are all involved in enzyme-substrate interactions.

What Kind of Interaction Is Not Involved in the Binding