Conformational shift in the  subunit of the G protein
A)6 - 3 - 5 - 1 - 2 - 4 - 7
B)3 - 6 - 5 - 1 - 7 - 2 - 4
C)6 - 3 - 5 - 1 - 7 - 2 - 4
D)6 - 7 - 3 - 5 - 1 - 2 - 4
E)6 - 3 - 5 - 1 - 7 - 4 - 2

Question

Quizplus · Accepted Answer

The conformational shift in the alpha subunit of the G protein occurs in a specific order of events, which is referred to as the canonical pathway. The correct order of this pathway is: 1) ligand binding to the G protein-coupled receptor, 2) activation of the receptor, 3) GDP release from the alpha subunit, 4) GTP binding to the alpha subunit, 5) conformational shift in the alpha subunit, 6) dissociation of the alpha subunit from the beta-gamma complex, and 7) activation or inhibition of downstream effector proteins. Choice C is the only option that correctly follows this order.

Conformational Shift in the  Subunit of the G Protein