What does the interaction between arrestin and clathrin promote?
A)the uptake of free hormone
B)the uptake of phosphorylated GPCRs into the cell by exocytosis
C)the uptake of phosphorylated GPCRs into the cell by endocytosis
D)the expulsion of phosphorylated GPCRs from the cell by exocytosis
E)the secretion of GPCRs

Question

Quizplus · Accepted Answer

The interaction between arrestin and clathrin promotes the uptake of phosphorylated GPCRs into the cell by endocytosis. Arrestin binds to phosphorylated GPCRs, preventing further signaling, and promotes the recruitment of clathrin to form a clathrin-coated pit, which allows the GPCR-arrestin complex to be internalized into the cell via endocytosis.

What Does the Interaction Between Arrestin and Clathrin Promote