How is signaling by an activated G _$\alpha$ subunit terminated? A)The bound GTP is hydrolyzed to GMP. B)The bound GDP is hydrolyzed to GTP. C)The bound GTP is hydrolyzed to GDP. D)The bound GDP is phosphorylated to GTP. E)The G _$\alpha$ subunit releases GDP and binds GTP.

Question

Quizplus · Accepted Answer

When the GF1F1F1S1_F1F1F10 subunit is activated, it exchanges its bound GDP molecule for GTP. However, this GTP-bound state is only temporary and the subunit must quickly return to its inactive GDP-bound state to terminate signaling. This is accomplished by hydrolysis of the bound GTP to GDP, which is catalyzed by the intrinsic GTPase activity of the GF1F1F1S1_F1F1F10 subunit. Once GDP is bound, the subunit is no longer active and signaling ceases.

How Is Signaling by an Activated G α\alphaα Subunit Terminated? A)The Bound GTP Is Hydrolyzed to

How Is Signaling by an Activated G _$\alpha$ Subunit Terminated?
A)The Bound GTP Is Hydrolyzed to