What is responsible for deactivating glycogen synthase kinase-3?
A)its phosphorylation by PKB
B)its dephosphorylation by protein phosphatase 1
C)its dephosphorylation by PKB
D)its phosphorylation by protein phosphatase 1
E)its degradation by PKB

Question

Quizplus · Accepted Answer

Glycogen synthase kinase-3 is deactivated when it is phosphorylated by PKB (also known as Akt). This phosphorylation inhibits the activity of glycogen synthase kinase-3 and allows for the activation of glycogen synthase, leading to glycogen synthesis. Dephosphorylation of glycogen synthase kinase-3 by protein phosphatase 1 would actually activate the enzyme, making choice B incorrect. PKB does not directly cause the degradation of glycogen synthase kinase-3, so choice E is also incorrect.

What Is Responsible for Deactivating Glycogen Synthase Kinase-3