What experimental evidence suggests that the N-terminal tails of histones participate in the formation of higher-order chromatin structure?
A)The tails cause histones to denature.
B)The tails when acetylated cause the dissolution of the 30-nm fibers.
C)Chromatin fibers prepared with H4 histones lacking their tails cannot fold into higher-order fibers.
D)Chromatin fibers prepared with H4 histones possessing longer tails cannot fold into higher-order fibers.
E)Chromatin fibers lacking tails are shorter.

Question

Quizplus · Accepted Answer

Chromatin fibers prepared with H4 histones lacking their tails cannot fold into higher-order fibers, suggesting that the tails of histones participate in the formation of higher-order chromatin structure. This experiment demonstrates the importance of the N-terminal tails in the organization of chromatin fibers.

What Experimental Evidence Suggests That the N-Terminal Tails of Histones