What is thought to maintain X chromosome inactivation?
A)repressive histone modifications
B)RNA inactivation
C)DNA methylation
D)localized DNA denaturation
E)both repressive histone modifications and DNA methylation

Question

Quizplus · Accepted Answer

X chromosome inactivation is maintained through a combination of repressive histone modifications and DNA methylation. The histone modifications prevent the transcription machinery from accessing the genes on the inactive X chromosome, while the DNA methylation marks the genes as inactive so future generations of cells also maintain the same inactivation pattern. RNA inactivation and localized DNA denaturation are not known to play a significant role in X chromosome inactivation.

What Is Thought to Maintain X Chromosome Inactivation