Where is the RNA polymerase II phosphorylated during its activation?
A)on the N-terminal end of the largest RNA polymerase II subunit
B)on the central 20 amino acids of the largest RNA polymerase II subunit
C)on the 3' end of the largest RNA polymerase II subunit
D)on the 5' end of the largest RNA polymerase II subunit
E)in the carboxyl-terminal domain (CTD)of the largest RNA polymerase II subunit

Question

Quizplus · Accepted Answer

RNA polymerase II is phosphorylated in the carboxyl-terminal domain (CTD) of the largest subunit. The CTD contains multiple repeats of the heptapeptide sequence YSPTSPS and phosphorylation of specific serine residues in these repeats plays a critical role in activation of RNA polymerase II.

Where Is the RNA Polymerase II Phosphorylated During Its Activation