What happens to a newly synthesized glycoprotein after the binding of calnexin or calreticulin to help the protein correctly complete its folding?
A)When the glycoprotein's folding is correctly completed,the remaining glucose on its oligosaccharide chain is eventually reduced and the glycoprotein is released from the chaperone.
B)The oligosaccharide chain is totally degraded
C)Nothing happens.
D)When the glycoprotein's folding is correctly completed,the remaining glucose on its oligosaccharide chain is eventually removed enzymatically and the glycoprotein is released from the chaperone.
E)The oligosaccharide chain is totally degraded.

Question

Quizplus · Accepted Answer

Calnexin or calreticulin binds to the glycoprotein to help it correctly fold in the ER. Once folding is complete, the remaining glucose residues on the oligosaccharide chain are enzymatically removed, allowing the glycoprotein to be released from the chaperone and proceed to further processing and transport. The oligosaccharide chain is not degraded entirely, as it is an essential part of glycoprotein function.

What Happens to a Newly Synthesized Glycoprotein After the Binding