What mediates the interaction between integral membrane proteins to be transported in COPII-coated vesicles and the COPII-coat?
A)ER export signals in the luminal tails of integral ER membrane proteins
B)ER export signals in the cytosolic tails of integral ER membrane proteins
C)ER export signals in ER phospholipids that interact with the membrane proteins
D)ER export signals in carbohydrates on the cytosolic tails of integral ER membrane proteins
E)ER export signals in carbohydrates on the luminal tails of integral ER membrane proteins

Question

Quizplus · Accepted Answer

ER export signals in the cytosolic tails of integral ER membrane proteins mediate the interaction between the proteins and the COPII-coat. These signals are recognized by specific receptors such as Sec24, which is a component of the COPII-coat. The luminal tails of integral ER membrane proteins do not contain ER export signals. ER phospholipids and carbohydrates on the cytosolic or luminal tails of the proteins are not directly involved in mediating the interaction with the COPII-coat.

What Mediates the Interaction Between Integral Membrane Proteins to Be