Typically,receptors for Hormones or Growth Factors Are Destroyed During Endocytosis,leading

Typically,receptors for hormones or growth factors are destroyed during endocytosis,leading to a reduction in the cell's sensitivity to further stimulation by that particular hormone or growth factor.This is a mechanism by which cells regulate their ability to respond to extracellular messengers.What is it called?

A) receptor annihilation
B) receptor down-regulation
C) super-signaling
D) endocytotic assignation
E) receptor up-regulation