The drugs that lower LDL concentration in the blood function by ________.
A)blocking a key cholesterol-degrading enzyme, HMG CoA reductase
B)activating a key cholesterol-degrading enzyme, HMG CoA reductase
C)blocking a key cholesterol synthesis enzyme, HMG CoA reductase
D)activating a key cholesterol synthesis enzyme, HMG CoA reductase
E)blocking a key cholesterol synthesis enzyme, HMG CoA oxidase

Question

Quizplus · Accepted Answer

Drugs that lower LDL concentration in the blood function by blocking a key cholesterol synthesis enzyme, HMG CoA reductase. This enzyme is responsible for catalyzing the rate-limiting step in cholesterol biosynthesis, so inhibiting it leads to a decrease in cholesterol production and subsequently, a decrease in LDL concentration. This class of drugs is commonly referred to as statins.

The Drugs That Lower LDL Concentration in the Blood Function