Why does targeting glucocerebrosidase to lysosomes in macrophages serve as a treatment for Gaucher's disease?
A)Glucocerebrosidase is normally denatured in the lysosomes.
B)Glucocerebrosidase is delivered to the precise sites in the cell where the deficiency is manifested,thus correcting the deficit.
C)Glucocerebrosidase denatures the cytoplasm from its location in the lysosomes correcting the deficit.
D)Glucocerebrosidase binds to the outer lysosome surface and breaks down glycogen in the cytoplasm.
E)Glucocerbrosidase is supposed to digest most of the enzymes in the lysosome.

Question

Quizplus · Accepted Answer

Gaucher's disease is caused by a deficiency in the enzyme glucocerebrosidase, which is responsible for breaking down a specific type of fat molecule. Targeting glucocerebrosidase to lysosomes in macrophages allows for the enzyme to be delivered to the precise sites in the cell where the deficiency is manifested, thus correcting the deficit. This approach is effective in treating Gaucher's disease because lysosomes are the primary site of lipid breakdown and recycling within cells. By delivering the missing enzyme directly to lysosomes, the accumulated lipid can be broken down and removed from the cell, alleviating the symptoms of the disease.

Why Does Targeting Glucocerebrosidase to Lysosomes in Macrophages Serve as a Treatment