You are investigating the interactions of integrin $\alpha$ and $\beta$ subunits and isolate the extracellular portion of an integrin as a soluble $\alpha$/$\beta$ heterodimer.The heterodimer lacks the associated transmembrane and cytoplasmic domains normally present as part of the molecule.You experimentally link the $\alpha$and $\beta$ subunits at the bases of their legs so that the ligand-binding regions of the $\alpha$and $\beta$subunits approach one another.Which of the following statements is true about the molecules formed?
A)The molecules bind their ligand tightly.
B)The molecules are unable to bind a ligand.
C)The molecules are cleaved.
D)The molecules denature their ligand.
E)The molecules denature and degrade.

Question

Quizplus · Accepted Answer

Integrins bind ligands through a conformational change in the extracellular portion of the molecule. Linking the F1F1F1S1F1F1F10 and F1F1F1S1F1F1F10 subunits would allow for this conformational change and the binding of a ligand. Therefore, the molecules formed would bind their ligand tightly.

You Are Investigating the Interactions of Integrin α\alphaα And β\betaβ Subunits and Isolate the Extracellular Portion of an Integrin as Subunits

You Are Investigating the Interactions of Integrin $\alpha$ And $\beta$ Subunits and Isolate the Extracellular Portion of an Integrin as Subunits