In which disease do individuals produce antibodies that bind to proteins present in hemidesmosmes? It causes the lower layer of the epidermis to lose attachment to the underlying basement membrane and thus to the underlying connective tissue layer of the dermis.The leakage of fluid into the space beneath the epidermis results in severe blistering of the skin.
A)epidermolysis bullosa
B)bullous pemphigoid
C)blisterosis
D)hemidesmosomosis
E)eczema

Question

Quizplus · Accepted Answer

The disease described is bullous pemphigoid. Individuals with this disease produce antibodies that bind to proteins in hemidesmosomes, which results in blistering of the skin due to loss of attachment between the basal layer of the epidermis and the underlying basement membrane. Epidermolysis bullosa is a genetic disorder characterized by blistering of the skin and other mucous membranes, but it is caused by defects in structural proteins, not autoantibodies. Blisterosis and hemidesmosomosis are not recognized medical conditions. Eczema is a chronic inflammatory skin condition, but it does not cause blistering due to loss of attachment between skin layers.

In Which Disease Do Individuals Produce Antibodies That Bind to Proteins