Once the structure of one member of a membrane protein family has been determined,researchers can usually apply a strategy called __________ to learn about the structure and activity of other members of the family.For example,solution of the structure of the bacterial potassium channel KcsA provided a lot of data that could be applied to the structure and mechanism of action of the much more complex eukaryotic potassium channels.
A)heterology modeling
B)homology mapping
C)homology modeling
D)protein mapping
E)homologous characterization

Question

Quizplus · Accepted Answer

Homology modeling involves using the known structure of one protein to predict the structure of other proteins that share a similar amino acid sequence. This strategy is often used for membrane protein families where determining the structure of every member is difficult or impossible. By using the known structure of one protein as a template, researchers can predict the structure and activity of other family members. This was done with the bacterial potassium channel KcsA, where the structure was used as a template to predict the structures and mechanisms of eukaryotic potassium channels.

Once the Structure of One Member of a Membrane Protein