Which interaction is most important in enhancing the solubility of macromolecules in water?

Question

Quizplus · Accepted Answer

H bonds are the most important interaction in enhancing the solubility of macromolecules in water. This is because water molecules themselves are held together by H bonds, and can form favorable interactions with macromolecules through H bonding as well. Hydrophobic interactions and nonpolar covalent bonds are actually unfavorable in water, as water molecules tend to exclude nonpolar substances. Van der Waals forces may contribute to solubility to some extent, but are generally weaker than H bonding.

Which Interaction Is Most Important in Enhancing the Solubility of Macromolecules