Which of the Following Statements Regarding the Sequence of Amino

Which of the following statements regarding the sequence of amino acids in proteins is NOT correct?

A) The solubility of proteins in water depends on their sequence of amino acids.
B) Sickle cell anemia is an example of the effect that the primary structure of a protein can have on its function.
C) The effect of substituting one amino acid for another in a protein can depend heavily on the polarity of the side groups involved.
D) Two proteins containing the same numbers and types of amino acids can have different functions.
E) Changing only one or two amino acids in a protein usually has little impact on its properties.