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What Effect,if Any,can the Substitution of One Amino Acid for Another

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What effect,if any,can the substitution of one amino acid for another in a protein have on the protein's function? For example,what if histidine were substituted for phenylalanine at a physiological pH of 7.4? What major difference do you see in their R groups? What effect,if any,can the substitution of one amino acid for another in a protein have on the protein's function? For example,what if histidine were substituted for phenylalanine at a physiological pH of 7.4? What major difference do you see in their R groups?

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Changing only one amino acid can drastic...

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