According to the First Law of Thermodynamics,the Energy of the Universe

According to the first law of thermodynamics,the energy of the universe is constant.Does this mean that $\Delta$ E is always equal to zero?

A) Yes, $\Delta$ E = 0 at all times,which is why q = -w.
B) No, $\Delta$ E does not always equal zero,but this is only due to factors like friction and heat.
C) No, $\Delta$ E does not always equal zero because it refers to the system's internal energy,which is affected by heat and work.
D) No, $\Delta$ E never equals zero because work is always being done on the system or by the system.
E) No, $\Delta$ E never equals zero because energy is always flowing between the system and surroundings.