A pathologist analyzes a resected colon with carcinoma,and she determines the tumor has penetrated deep into the colonic wall.Furthermore,there are a higher number of CD8+ T cells in and around the cancer,compared to most colon cancers analyzed in this way.What is the significance of the T cell finding?
A)Worse prognosis.
B)Better prognosis
C)No correlation with prognosis
D)More likely respond to anti-PD-1 therapy.
E)Patient likely to develop autoimmunity

Question

Quizplus · Accepted Answer

The presence of relatively high numbers of CD8+ CTL and CD4+ Th1 cells in and around resected colon cancers is correlated with a better prognosis after surgery,and this is thought to reflect more effective anti-tumor T cell responses against residual tumor cells in the patient.Surprisingly,the presence of high numbers of T cells does not correlate with responsiveness to checkpoint blockade therapy,and most colon cancer patients,do not respond to tanti-PD-1 therapy.

A Pathologist Analyzes a Resected Colon with Carcinoma,and She Determines