Which one of the following statements about humoral immune responses is true?
A)Naive B cells are required for initiation of primary responses and memory B cells are required for initiation of secondary responses.
B)Antibody responses to bacterial polysaccharide antigens require CD4+ helper T cells.
C)Heavy chain isotype switching typically occurs in response to bacterial polysaccharide antigens.
D)Affinity maturation does not require T follicular helper T cells.
E)Antibody-secreting cells generated during a humoral immune response live for only a few hours.

Question

Quizplus · Accepted Answer

Humoral responses require antigen-dependent activation of B cells through binding of the antigen to membrane Ig on naive B cells or on memory B cells,for primary or secondary responses,respectively.In most cases,nonprotein antigens do not stimulate isotype switching or affinity maturation because these changes require T cell help,and only protein antigens can stimulate T cells.For both nonprotein and protein antigens,antibody-secreting cells that are generated may live for months,often in the bone marrow.

Which One of the Following Statements About Humoral Immune Responses