CAR T cells have shown remarkable efficacy in treating hematological malignancies . Figure Q17) In this cartoon, the component of the CAR indicated by the arrow is composed of:
A) A T-cell receptor specific for mesothelin
B) The ligand that normally binds to mesothelin
C) The Fab fragment of an anti-mesothelin antibody
D) A co-stimulatory receptor signaling domain
E) The CD3 signaling components of the T-cell receptor

Question

CAR T cells have shown remarkable efficacy in treating hematological malignancies .  Figure Q17) In this cartoon, the component of the CAR indicated by the arrow is composed of:
A) A T-cell receptor specific for mesothelin 
B) The ligand that normally binds to mesothelin 
C) The Fab fragment of an anti-mesothelin antibody 
D) A co-stimulatory receptor signaling domain 
E) The CD3 signaling components of the T-cell receptor

Quizplus · Accepted Answer

The component of the CAR indicated by the arrow is composed of the Fab fragment of an anti-mesothelin antibody, which specifically targets the cancer-associated protein mesothelin expressed on tumor cells. This antibody fragment is fused to the intracellular signaling domain of the T-cell receptor and co-stimulatory molecules, allowing T cells to recognize and attack cancer cells expressing mesothelin.

CAR T Cells Have Shown Remarkable Efficacy in Treating Hematological