Large clinical trials have been performed to compare the vaccine efficacy of the live-attenuated influenza virus vaccine with that of the inactivated virus vaccine. In all, data from over 25,000 children aged 6-71 months were analyzed. The conclusion was that the children who received the live-attenuated vaccine reported 50% fewer cases of influenza than those who received the inactivated vaccine. One difference in the immune response elicited by the live-attenuated versus the inactivated vaccine is: A) The live-attenuated vaccine elicits higher antibody titers than the inactivated vaccine. B) The live-attenuated vaccine elicits antibodies with higher affinities than the inactivated vaccine. C) The live-attenuated vaccine elicits increased numbers of CD4 T_FH cells than the inactivated vaccine. D) The live-attenuated vaccine elicits antiviral CD8 effector responses but the inactivated vaccine does not. E) The live-attenuated vaccine induces antibodies of the IgA isotype, but the inactivated vaccine does not.

Question

Quizplus · Accepted Answer

The live-attenuated vaccine is capable of inducing a broader immune response, including the activation of CD8 T cells, which play a crucial role in clearing viral infections. In contrast, inactivated vaccines primarily stimulate antibody production without effectively inducing a strong CD8 T cell response.

Large Clinical Trials Have Been Performed to Compare the Vaccine