Studies performed in mice have revealed one important component affecting the altered immune response in individuals undergoing malnutrition or starvation. In these studies, mice were placed on a starvation diet for several days, and then immunized with a protein antigen in an adjuvant. One group of starved mice were given injections of 'compound X' for 48 hours, starting at the time of immunization. Seven days later, draining lymph nodes were isolated, and T cell responses were measured in vitro following stimulation with antigen. The results are shown in Figure .
'Compound X' is most likely:
A) IL-1$\beta$
B) Leptin
C) TNF-$\alpha$
D) IL-10
E) Double-stranded RNA

Question

Studies performed in mice have revealed one important component affecting the altered immune response in individuals undergoing malnutrition or starvation. In these studies, mice were placed on a starvation diet for several days, and then immunized with a protein antigen in an adjuvant. One group of starved mice were given injections of 'compound X' for 48 hours, starting at the time of immunization. Seven days later, draining lymph nodes were isolated, and T cell responses were measured in vitro following stimulation with antigen. The results are shown in Figure .  
 'Compound X' is most likely:
A) IL-1$\beta$ 
B) Leptin 
C) TNF-$\alpha$ 
D) IL-10 
E) Double-stranded RNA

Quizplus · Accepted Answer

The studies show that 'Compound X' affects the altered immune response in individuals undergoing malnutrition or starvation. The only option related to hunger and metabolism is Leptin. Leptin is a hormone produced by adipose tissue that plays a crucial role in regulating energy intake and expenditure. During starvation, leptin levels decrease, leading to immune dysfunction. Therefore, injectable leptin can restore the immune response in malnourished individuals.

Studies Performed in Mice Have Revealed One Important Component Affecting β\betaβ

Studies Performed in Mice Have Revealed One Important Component Affecting $\beta$