The first drug treatment for HIV licensed in the US was zidovudine (AZT), a reverse transcriptase inhibitor. However, AZT has now been completely replaced by HAART as the recommended treatment for HIV-infected individuals. The use of HAART, rather than AZT, is preferred because:
A) HAART includes a reverse transcriptase inhibitor that is more potent than AZT.
B) HAART only needs to be taken once per week compared to daily AZT treatment.
C) HAART has fewer side effects than AZT.
D) HAART is a combination therapy that reduces the possibility of viral escape mutants.
E) HAART is less expensive than AZT.

Question

Quizplus · Accepted Answer

HAART is a combination therapy that targets multiple stages of the HIV life cycle and therefore reduces the likelihood of developing viral resistance, including escape mutants. AZT alone led to the development of resistance, making it less effective as a treatment option.

The First Drug Treatment for HIV Licensed in the US