The TNF family of cytokines and their receptors are critical for the development of secondary lymphoid organs, such as the lymph nodes and Peyer's patches. As a consequence, knockout mice lacking expression of LT- fail to develop most of these structures. Reconstitution of irradiated LT- -deficient mice with bone marrow stem cells from wild-type mice (e.g., LT- -sufficient) would:
A) Restore all missing lymphoid structures in the recipient mice
B) Restore the missing lymphoid structures but not the missing follicular dendritic cells in the recipient mice
C) Restore the missing follicular dendritic cells but not the missing lymphoid structures in the recipient mice
D) Have no effect on any lymphoid structures in the recipient mice
E) Only restore the proper organization of B cell follicles in the recipient mice
Correct Answer:
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