Wiskott-Aldrich Syndrome Is an Immunodeficiency Disease That Causes a Defect

Wiskott-Aldrich syndrome is an immunodeficiency disease that causes a defect in antibody responses. The most severe defects are in antibody responses to protein antigens, which are dependent on CD4 effector T_FH cells providing cytokines to the B cell. The protein defective in individuals with the disease, known as WASp, functions in cytoskeletal reorganization and polarization through its role in promoting actin polymerization. This immune defect could be fixed by a gene therapy approach that restored WASp expression in:

A) Antigen-presenting cells such as dendritic cells
B) B cells
C) B cells and T cells
D) T cells
E) T cells and antigen-presenting cells