The mouse thymus normally contains about 1–2 x 108 thymocytes, the vast majority of which are CD4+CD8+ (double-positive) cells. When thymocytes from mice with a gene deficiency in the TCR$\alpha$ locus are compared with those from TCR$\beta$-deficient mice, a striking difference between the two different knockout lines is observed, as shown in Figure in a simplified version of flow cytometry data. The numbers of thymocytes in each thymus is indicated below the plots. -What is the explanation for the difference in thymocyte subsets and cell numbers observed when comparing TCR$\alpha$^-/- to TCR$\beta$^-/- thymocytes?

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The Answer of The mouse thymus normally contains about 1–2 x 108 thymocytes, the vast majority of which are CD4+CD8+ (double-positive) cells. When thymocytes from mice with a gene deficiency in the TCR$\alpha$ locus are compared with those from TCR$\beta$-deficient mice, a striking difference between the two different knockout lines is observed, as shown in Figure in a simplified version of flow cytometry data. The numbers of thymocytes in each thymus is indicated below the plots. -What is the explanation for the difference in thymocyte subsets and cell numbers observed when comparing TCR$\alpha$^-/- to TCR$\beta$^-/- thymocytes?

The Mouse Thymus Normally Contains About 1–2 X 108 Thymocytes α\alphaα

The Mouse Thymus Normally Contains About 1–2 X 108 Thymocytes $\alpha$