The repertoire of T-cell receptors, like that of antibodies, is formed by the random rearrangement of multiple gene segments that combine to generate the variable domain of each receptor subunit. The bias of T-cell receptors for binding to peptide:MHC complexes, rather than to all possible antigenic structures like antibodies, is simply the result of positive selection in the thymus.

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The Answer of The repertoire of T-cell receptors, like that of antibodies, is formed by the random rearrangement of multiple gene segments that combine to generate the variable domain of each receptor subunit. The bias of T-cell receptors for binding to peptide:MHC complexes, rather than to all possible antigenic structures like antibodies, is simply the result of positive selection in the thymus.

The Repertoire of T-Cell Receptors, Like That of Antibodies, Is