Wiskott-Aldrich syndrome is an immunodeficiency disease due to mutations in the gene encoding WASp. Individuals with this disease make poor antibody responses to protein antigens, due to impaired T cell help for B cells. WASp-deficient T cells are likely impaired in providing adequate help to B cells due to:

Question

Quizplus · Accepted Answer

WASp is important for cytoskeletal reorganization, which allows for directed cytokine secretion by T cells. Without WASp, T cells may not be able to properly interact with B cells and provide the necessary cytokine support for B cell activation and antibody production.

Wiskott-Aldrich Syndrome Is an Immunodeficiency Disease Due to Mutations in the Gene