The adaptive immune system developed a strategy for monitoring the proteins synthesized in virtually any cell in the body, thereby preventing pathogens from 'hiding out' by adopting an intracellular lifestyle. To accomplish this, the immune system:
A) Co-opted the ubiquitin-proteasome system used by cell for protein turnover
B) Created a novel pathway using the immunoproteasome for generating peptides
C) Created a novel pathway to express foreign proteins on the cell surface
D) Took advantage of proteolytic enzymes present in endocytic vesicles
E) Engineered an immune-specific ubiquitin molecule for tagging foreign proteins

Question

Quizplus · Accepted Answer

The immune system co-opted the ubiquitin-proteasome system, which is used by cells for protein turnover, to process intracellular proteins into peptides that can be presented on MHC class I molecules, allowing the immune system to monitor intracellular proteins.

The Adaptive Immune System Developed a Strategy for Monitoring the Proteins