Macrophages express multiple types of receptors on their surface that stimulate phagocytosis of microbes, leading to pathogen internalization and destruction. Many of these receptors, such as Dectin-1, rely on direct recognition of a PAMP on the pathogen surface. However, some receptors that stimulate phagocytosis rely on soluble factors (not associated with the phagocyte membrane) to identify and mark the pathogen for uptake by the phagocyte. One such receptor is:
A) The mannose receptor
B) The class A scavenger receptor
C) The lipid receptor
D) The macrophage C-type lectin receptor
E) The complement receptor

Question

Quizplus · Accepted Answer

The complement receptor on macrophages relies on soluble factors, specifically components of the complement system, to identify and mark pathogens for phagocytosis. This process, known as opsonization, involves the coating of pathogens with complement proteins, which are then recognized by complement receptors on phagocytes, facilitating pathogen uptake and destruction.

Macrophages Express Multiple Types of Receptors on Their Surface That