A key feature of TLR signaling is the ability to induce inflammatory cytokine gene expression extremely rapidly following TLR stimulation. This is accomplished by signaling pathways using several mechanisms to activate transcription factors that are already present in the cell prior to TLR stimulation, but are kept in an inactive state. These signaling pathways use all of the following mechanisms EXCEPT:
A) Induced ubiquitination leading to protein degradation
B) Induced ubiquitination inducing protein-protein interactions
C) Induced phosphorylation leading to nuclear translocation
D) Induced phosphorylation leading to kinase activation
E) Induced phosphorylation preventing protein degradation

Question

Quizplus · Accepted Answer

The correct answer is E because TLR signaling pathways typically do not use induced phosphorylation to prevent protein degradation as a mechanism to activate transcription factors. Instead, they utilize mechanisms such as induced ubiquitination (for protein degradation or inducing protein-protein interactions), and induced phosphorylation (for nuclear translocation or kinase activation) to activate transcription factors that are already present in the cell in an inactive state.

A Key Feature of TLR Signaling Is the Ability to Induce