Patients with recurrent infections of Neisseria meningitidis, an extracellular bacterial pathogen that causes meningitis, were examined to determine the underlying cause of their immunodeficiency. A subset of these patients were found to have defects in complement activation on the bacterial surface, a process that for this bacterium is dominated by alternative complement activation leading to C3b deposition on the pathogen surface. When neutrophils from these patients were examined in vitro, the results in Figure were obtained.
Based on these data, the identity of the green neutrophil mediator in Figure is likely to be:
A) Complement factor B
B) The C3 convertase
C) Factor P (properdin)
D) C3b
E) Mannose-binding lectin (MBL)
Correct Answer:
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