Individuals with defects in T cell development have a severe immunodeficiency disease called SCID (severe combined immunodeficiency disease). In these individuals, the absence of all T cells causes defects in both cell-mediated (T cell-based) and humoral (antibody-based) immune responses. The defect in antibody responses in SCID patients is due to:
A) The important role of T cells in regulating B cell development in the bone marrow
B) The inter-dependence of T cells and B cells for the normal development of secondary lymphoid organs.
C) The absence of phagocytic cells needed for antibody-dependent pathogen clearance in SCID patients
D) The poor survival of B cells in patients with defects in their T cells
E) The important role of T follicular helper cells in generating protective antibody responses

Question

Quizplus · Accepted Answer

T follicular helper cells, a subset of T cells, play a crucial role in helping B cells produce high-affinity antibodies and undergo class switching, which are essential for generating effective and long-lasting antibody responses. In SCID patients, the absence of T cells, including T follicular helper cells, leads to compromised antibody responses.

Individuals with Defects in T Cell Development Have a Severe