Chronic ethanol ingestion alters carbohydrate metabolism and leads to a fatty liver due to an increase in which of the following?

Question

Quizplus · Accepted Answer

Chronic ethanol ingestion results in an increase in NADH levels which affects the metabolism of carbohydrates and leads to the accumulation of fatty acids in the liver, resulting in fatty liver disease. This is because NADH is required for the conversion of pyruvate to acetyl-CoA, which is a key step in fatty acid synthesis. The excess NADH generated from ethanol metabolism inhibits this conversion, resulting in the accumulation of pyruvate and the diversion of excess acetyl-CoA into the synthesis of fatty acids.

Chronic Ethanol Ingestion Alters Carbohydrate Metabolism and Leads to a Fatty