Type I diabetes leads to ______________ in the liver.
A) increased glucose transport
B) increased glycogen synthesis
C) a decrease in fructose 2,6-phosphate
D) a decrease in gluconeogenesis
E) All of the above.

Question

Quizplus · Accepted Answer

In type I diabetes, insulin production is reduced, leading to decreased activation of phosphofructokinase-2, an enzyme that produces fructose 2,6-bisphosphate. This in turn decreases the activity of phosphofructokinase-1, ultimately leading to a decrease in glycolysis and an increase in gluconeogenesis. Glycogen synthesis is not affected in the liver. Therefore, only choice C is correct.

Type I Diabetes Leads to ______________ in the Liver